Synthetic Organic Chemistry

Type

Core

Course Code

ΑΣΦΔ14

Teaching Semester

A semester

Teaching Hours per Week

4

ECTS Credits

10

Syllabus

  1. Introduction to synthetic organic chemistry
    1. The past, present and future of organic synthesis
    2. Structures and mechanisms; the basics
      1. Structure and stability of organic compounds (e.g. drawing, Lewis structures, hybridization,
        aromaticity)
    3. pKa, tautomerism
    4. Mechanisms (draw)
  1. Aliphatic/aromatic nucleophilic substitution
    1. Williamson synthesis
    2. Stork enamine synthesis
    3. Mitsunobu reaction
    4. SNAr; oxygen nucleophiles
  1. Addition to C-C multiple bonds
    1. Michael reaction
    2. Simmons-smith cyclopropanation
    3. Sharpless asymmetric epoxidation
  1. Addition to C-X multiple bonds
    1. Aldol reaction
    2. Grignard reaction
    3. Knoevenagel condensation
    4. Mannich reaction
    5. Wittig reaction
  1. Selected Metal-Mediated Cross-Coupling Reactions
    1. Ring-closing metathesis
    2. Suzuki reaction
    3. Stille reaction
    4. Heck reaction
    5. Sonogashira reaction
  1. Oxidations/reductions
    1. Baeyer-Villiger oxidation
    2. Dess-Martin oxidation
    3. Swern oxidation
    4. Wacker oxidation
  1. Pericyclic reactions
    1. Alder (ene) reaction
    2. DeMayo cycloaddition
    3. Paterno-Büchi reaction
    4. (hetero)Diels-Alder reaction
    5. 1,3-dipolar
  1. Synthesis of common heterocycles
  2. Combinatorial chemistry, MCRs, automated synthesis
    1. Principles and strategy
    2. Ugi and Passerini reaction; applications
  1. Retrosynthesis and strategy in organic synthesis
    1. Synthetic route development of selected contemporary pharmaceutical drugs
  1. Practical Chemistry concepts: Things they don’t teach you in school
  2. Presentations/projects from students

Learning Outcomes

Teaching of modern synthetic organic chemistry and the way to retro-synthetically analyse complicated molecular structures. Very detailed discussion of the most synthetically useful reactions accomplished through the teaching of the total synthesis of structurally complex natural products.

Student Performance Evaluation

Written examination

Prerequisite courses

The knowledge of the undergraduate courses in organic chemistry (Organic Chemistry I and II and III)

Navigate to Courses

Biocatalysis and Applications in Organic Synthesis

Biological Membrane Systems

Chemistry of Natural Products

Medicinal Chemistry

Nuclear Magnetic Resonance Spectroscopy (NMR) – Theory and Applications

Organic Photochemistry

Protein Engineering

Stereochemistry – Mechanisms of Organic Reactions

Structure and Function of Proteins

Synthetic Organic Chemistry

Frequently asked questions

Who can apply?

The program is addressed to graduates of Faculties of Sciences and Technology, Faculties of Engineering, Schools of Agriculture, and other Faculties of related subjects of Higher Education Institutions.

What is the methodology used?

The training curriculum consists of a number of specialized lectures on the above mentioned topics, laboratory and field work, hands-on exercises on data analysis and numerical modeling.

Is the programme full time?

Yes, and it lasts 4 semesters

What is the cost of the programme?

There are no tuition fees.

Is the programme tought in English?

The courses are taught in Greek or English depending on the audience. The Master thesis can be written in Greek or English after approval from the overseen committee.