Biomaterials and Biomedical Engineering
Type
Core
Course Code
ΜΕMΥ-504
Teaching Semester
Semester B
ECTS Credits
10
Course Website
https://teleclass.materials.uoc.gr/courses/PGRAD115/Syllabus
- Natural and synthetic biomaterials used in biomedicine (metal, metal alloys, ceramics, natural and synthetic polymers). Definitions and properties.
- Princicles of biomaterial functionalization.
- Rational design of synthetic biomaterials.
- Principles in Tissue Engineering,
- Bone, cartilage, dental, cardiovascular tissue engineering
- Cell adhesion
- Mechanical properties and biocompatibility of implantable biomaterials
- Methods & tools for mathematical modelling of tissue constructs and biomedical systems: solid mechanics, fluid mechanics, dynamic systems.
- Biofabrication methods: capabilities, technologies, hardware.
- Applications of biomaterials in biomedical engineering.
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Lecture program Spring Semester 2024
Learning Outcomes
The course outline includes the study of biomaterials and biomolecules, their physicochemical and mechanical properties, their degradation mechanisms, their biocompatibility criteria and evaluation, the biological responses following an implantation. The learning goals that students should have achieved at the end of the lesson are the following:
- To become familiar with the properties and attributes of biomaterials.
- To become familiar with biomaterial fuctionalization methodologies.
- To be able for principle-based design of biomaterials and apply them in biomedical research and medicine.
- To know the basic methods for the mathematical modelling of tissue constructs and biomedical systems.
- To understand the need of biomolecule functionalization.
- To consolidate the notions of the structural mechanisms used by Nature to create materials with defined properties.
- To use their knowledge in the design of biocompatible materials.
- To be conceptually prepared to perform a Masters thesis in a research laboratory in the area of biomolecules, biomaterials, bioengineering, tissue engineering and regenerative medicine.
The course according to the European Qualifications Framework for Lifelong Learning belongs to level 7.
Recommended Bibliography
- Bioconjugate Techniques, Greg T. Hermanson, Academic Press, Inc., 2008
- J. S. Temenoff, A. G. Mikos, Biomaterials: The Intersection of Biology and Materials Science, 2nd edition, Pearson, 2022.
- C. M. Agrawal, J. L. Ong, M. R. Appleford, G. Mani, “Introduction to Biomaterials Basic Theory with Engineering Applications” Cambridge Texts in Biomedical Engineering, 2013.
- “An Introduction to Biomaterials, Second edition” Ed. J. Hollinger, Taylors and Francis, 2012.
- J. P. Fisher, A.G. Mikos, J.D. Bronzino “Tissue Engineering”, CRC Press, 2007
- Cindy Chung, Jason A. Burdick, Engineering cartilage tissue, Advanced Drug Delivery Reviews 60, 243–262, 2008
- B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, “Molecular Biology of the Cell, 4th edition”, Garland Science 2002, chapter 19
- Stephanie Willerth, Shelly Sakiyama-Elbert, Stem book, Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery
Related academic journals
- Tissue Engineering Part A, B & C, Mary Ann Liebert
- Journal of Tissue Engineering and Regenerative Medicine, Wiley
- Biomaterials, Elsevier
- Acta Biomaterialia, Elsevier
- Advanced Healthcare Materials, Wiley
- Biomaterials Science and Engineering, ACS
- Biomaterials Science, RCS
- Biomacromolecules, ACS
- Annals of biomedical engineering, Springer
- Nature biomedical engineering, Springer
- Nature reviews bioengineering, Springer
Student Performance Evaluation
Students are evaluated by a final written examination in English that includes critical development of topics.
Students have the right to view their exam scripts after the grading results are published and to ask questions.