Tissue Engineering

Syllabus

The course covers the following modules:

• Structure of tissues, organs and organ systems. Case studies.
• Introduction – major concepts of tissue engineering.
• Biomaterials in tissue engineering: types, fabrication, characteristics, modification, characterization, case studies.
• Stem cells in tissue engineering: types, characterization, case studies.
• Drug delivery systems.
• Biofabrication: methods, hardware, case studies.
• Mathematic modelling in tissue engineering: solid mechanics, fluid mechanics, dynamic systems. Overview of relevant software.
• Applications of tissue engineering in regenerative medicine: cases of induced regeneration in the therapy of tissue loss or organ function loss.
• Applications of tissue engineering in drug delivery: concepts, technologies, characterization, case studies.
• Applications of tissue engineering in in vitro tissue organs: types, technologies, case studies.

Learning Outcomes

Students will

• get acquainted with the structure of various tissues, organs and organ systems.
• get acquainted with basic principles of developmental biology.
• know the components of tissue constructs: biomaterials, cells and bioactive molecules.
• know the various types of biomaterials utilized in tissue engineering.
• know the basic biology and applications of stem cells in tissue engineering.
• know the basic biofabrication methods utilized in tissue engineering.
• know the basic principles of mechanics (solid mechanics, fluid mechanics, dynamics) that describe tissue constructs.
• know the major experimental means used for tissue construct characterization.
• be exposed to the state of the art of the major applications of tissue engineering: emphasis on regenerative medicine grafts, drug delivery systems, in vitro tissue models.

Recommended Bibliography

J.P. Fisher, A.G. Mikos, J.D. Bronzino “Tissue Engineering”, CRC Press, 2007.